Within Health Equity 2020, the main focus is on capacity development at a regional level. Therefore, the question what can and what cannot be done at a regional level is of major interest. “Regions” and regional policy development vary due to differences in political and administrative autonomy and responsibilities. But even if a region is only a “statistical region”, it is important to assess opportunities of stakeholders within the region as well as opportunities for co-operation in regional networks. It is necessary to identify the stakeholders being (potentially) involved in policy development, from the health sector as well as relevant other sectors. But the focus should not be limited to the political system in a more narrow sense; it should also include stakeholders from the private sector and the civil society (NGOs).